Comparison 2. Subcutaneous sumatriptan 6 mg versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain‐free at 2 h	11	2522	Risk Ratio (M‐H, Fixed, 95% CI)	3.85 [3.32, 4.46]
2 Pain‐free at 1 h	14	3592	Risk Ratio (M‐H, Fixed, 95% CI)	5.55 [4.55, 6.77]
3 Headache relief at 1 h	21	5177	Risk Ratio (M‐H, Fixed, 95% CI)	2.71 [2.51, 2.93]
4 Headache relief at 2 h	12	2738	Risk Ratio (M‐H, Fixed, 95% CI)	2.50 [2.29, 2.73]
5 24 h sustained pain‐free	2	752	Risk Ratio (M‐H, Fixed, 95% CI)	2.18 [1.61, 2.95]
6 Use of rescue medication	9		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 Up to 24 h after initial dosing	5	987	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.45, 0.60]
6.2 Up to 2 h after initial dosing	4	508	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.27, 0.44]
7 Relief of associated symptoms	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 Relief of nausea at 2 h	4	667	Risk Ratio (M‐H, Fixed, 95% CI)	2.22 [1.87, 2.64]
7.2 Relief of photophobia at 2 h	2	631	Risk Ratio (M‐H, Fixed, 95% CI)	1.89 [1.59, 2.24]
8 Relief of functional disability	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 Any functional disability at baseline to none at 2 hours	2	750	Risk Ratio (M‐H, Fixed, 95% CI)	3.40 [2.66, 4.35]
8.2 Moderate or severe functional disability to mild or none at 1 hour	3	1328	Risk Ratio (M‐H, Fixed, 95% CI)	3.21 [2.68, 3.84]
9 Any adverse event within 24 h	9	1342	Risk Ratio (M‐H, Fixed, 95% CI)	2.08 [1.75, 2.47]
10 Any adverse event withdrawal	12	3287	Risk Ratio (M‐H, Fixed, 95% CI)	2.11 [0.90, 4.96]
11 Pain‐free at 2 h ‐ effect of size	11	2522	Risk Ratio (M‐H, Fixed, 95% CI)	3.85 [3.32, 4.46]
11.1 Studies containing at least 50 participants in each treatment arm	6	1976	Risk Ratio (M‐H, Fixed, 95% CI)	3.57 [3.03, 4.20]
11.2 Studies containing one or more treatment arms with fewer than 50 participants	5	546	Risk Ratio (M‐H, Fixed, 95% CI)	5.29 [3.69, 7.58]
12 Pain‐free at 1 h ‐ effect of size	14	3592	Risk Ratio (M‐H, Fixed, 95% CI)	5.55 [4.55, 6.77]
12.1 Studies containing at least 50 participants in each treatment arm	8	2985	Risk Ratio (M‐H, Fixed, 95% CI)	5.53 [4.45, 6.88]
12.2 Studies containing one or more treatment arms with fewer than 50 participants	6	607	Risk Ratio (M‐H, Fixed, 95% CI)	5.64 [3.42, 9.29]
13 Headache relief at 1 h ‐ effect of size	21	5177	Risk Ratio (M‐H, Fixed, 95% CI)	2.71 [2.51, 2.93]
13.1 Studies containing at least 50 participants in each treatment arm	10	4040	Risk Ratio (M‐H, Fixed, 95% CI)	2.73 [2.50, 2.99]
13.2 Studies containing one or more treatment arms with fewer than 50 participants	11	1137	Risk Ratio (M‐H, Fixed, 95% CI)	2.65 [2.26, 3.10]
14 Headache relief at 2 h ‐ effect of size	12	2738	Risk Ratio (M‐H, Fixed, 95% CI)	2.50 [2.29, 2.73]
14.1 Studies containing at least 50 participants in each treatment arm	7	2192	Risk Ratio (M‐H, Fixed, 95% CI)	2.45 [2.22, 2.70]
14.2 Studies containing one or more treatment arms with fewer than 50 participants	5	546	Risk Ratio (M‐H, Fixed, 95% CI)	2.74 [2.24, 3.36]
15 Pain‐free at 1 h ‐ effect of missing data	14	3592	Risk Ratio (M‐H, Fixed, 95% CI)	5.55 [4.55, 6.77]
15.1 Studies with no missing data	12	3208	Risk Ratio (M‐H, Fixed, 95% CI)	5.01 [4.09, 6.14]
15.2 Studies with missing data	2	384	Risk Ratio (M‐H, Fixed, 95% CI)	35.63 [8.87, 143.18]
16 Headache relief at 1 hour ‐ effect of missing data	21	5177	Risk Ratio (M‐H, Fixed, 95% CI)	2.71 [2.51, 2.93]
16.1 Studies with no missing data	19	4793	Risk Ratio (M‐H, Fixed, 95% CI)	2.56 [2.36, 2.77]
16.2 Studies with missing data	2	384	Risk Ratio (M‐H, Fixed, 95% CI)	9.64 [5.66, 16.42]
17 Headache relief at 2 hours ‐ effect of missing data	12	2738	Risk Ratio (M‐H, Fixed, 95% CI)	2.50 [2.29, 2.73]
17.1 Studies with no missing data	10	2354	Risk Ratio (M‐H, Fixed, 95% CI)	2.26 [2.07, 2.47]
17.2 Studies with missing data	2	384	Risk Ratio (M‐H, Fixed, 95% CI)	7.39 [4.78, 11.41]