Summary of results A: Pain‐free and headache relief in placebo controlled studies
	Studies	Attacks treated	Treatment (%)	Placebo (%)	Relative risk (95% CI)	NNT (95% CI)
Pain‐free at 2 hours
Sumatriptan 4 mg	2	664	49	9	4.8 (3.2 to 7.2)	2.5 (2.2 to 3.0)
Sumatriptan 6 mg	13	2522	59	15	3.9 (3.3 to 4.5)	2.3 (2.1 to 2.4)
Sumatriptan 6 mg (+ 6 mg)	3	388	50	11	4.6 (2.9 to 7.4)	2.6 (2.1 to 3.2)
Pain‐free at 1 hour
Sumatriptan 4 mg	2	664	33	6	4.7 (2.8 to 7.7)	3.8 (3.2 to 4.8)
Sumatriptan 6 mg	16	3592	41	7	5.6 (4.6 to 6.8)	2.9 (2.7 to 3.2)
Sumatriptan 8 mg	2	308	46	6	7.1 (3.8 to 13)	2.5 (2.0 to 3.2)
Headache relief at 1 hour
Sumatriptan 4 mg	2	664	66	25	2.6 (2.0 to 3.2)	2.5 (2.1 to 3.0)
Sumatriptan 6 mg	24	5177	71	26	2.7 (2.5 to 2.9)	2.2 (2.1 to 2.4)
Sumatriptan 8 mg	3	361	80	23	3.6 (2.7 to 4.7)	1.7 (1.5 to 2.0)
Headache relief at 2 hours
Sumatriptan 4 mg	2	664	70	22	3.1 (2.4 to 4.0)	2.1 (1.8 to 2.5)
Sumatriptan 6 mg	14	2738	79	31	2.5 (2.3 to 2.7)	2.1 (2.0 to 2.2)
Sumatriptan 6 mg (+6 mg)	6	1728	79	32	2.4 (2.1 to 2.7)	2.1 (1.9 to 2.3)
Sustained pain‐free during the 24 hours postdose
Sumatriptan 6 mg	5	1336	31	15	2.2 (1.8 to 2.8)	6.1 (4.8 to 8.2)