Study ID	Treatment	Headache relief 1 h	Headache relief 2 h	Pain‐free 1 h	Pain‐free 2 h	Sustained headache relief 24 h	Sustained pain‐free 24 h	Use of rescue medication
Akpunonu 1995	(1) Sumatriptan 6 mg, n = 88 (2) Placebo, n = 48	No data	No data	No data	No data	No data	No data	No data
Bates 1994	(1) Sumatriptan 6 mg, n = 90 (88 for efficacy, 47 with moderate or severe baseline pain intensity) (2) Placebo, n = 87 (83 for efficacy, 35 with moderate or severe baseline pain intensity)	(1) 24/47 (2) 10/35	No data	No data	No data	No data	No data	No data
Bousser 1993	(1) Sumatriptan 6 mg, n = 49 (41 for 1st attack efficacy) (2) Placebo, n = 47 (40 for 1st attack efficacy)	(1) 29/41 (2) 8/40	No data	(1) 14/41 (2) 4/40	No data	No data	No data	No data
Cady 1991	Study 1 (1) Sumatriptan 6 mg, n = 384 (2) Placebo, n = 190 Study 2 (1) Sumatriptan 6 mg, n = 350 (2) Placebo, n = 180	Pooled results for Study 1 and Study 2 (1) 515/734 (2) 81/370	No data	Pooled results for Study 1 and Study 2 (1) 356/734 (2) 35/370	No data	No data	No data	No data
Cady 1993	(1) Sumatriptan 6 mg, n = 166 (128 treating first attack with moderate or severe baseline pain intensity) (2) Placebo, n = 144 (42 treating first attack with moderate or severe baseline pain intensity)	1st attack: (1) 100/128 (2) 16/42	No data	1st attack: (1) 41/128 (2) 3/42	No data	(1) 39/128 (2) 5/42	(1) 26/128 (2) 5/42	No data
Cady 1998	(1) Sumatriptan 6 mg, n = 67 (2) Placebo, n = 68 (65 for efficacy)	No data	No data	No data	No data	No data	No data	At 24 h: (1) 5/67 (2) 20/65
Dahlof 1992	(1) Sumatriptan 8 mg, n = 27 (2) Placebo, n = 27	(1) 23/27 (2) 3/27	(1) 23/27 (2) 9/27	No data	(1) 17/27 (2) 0/27	No data	No data	At 2 h: (1) 3/27 (2) 24/27
Dahlof 1998	(1) Sumatriptan 6 mg, n = 47 (2) Naratriptan 0.5 mg, n = 60 (3) Naratriptan 1 mg, n = 55 (4) Naratriptan 2.5 mg, n = 42 (5) Naratriptan 5 mg, n = 34 (6) Naratriptan 10 mg, n = 34 (7) Placebo, n = 63	(1) 41/47 (2) 36/60 (3) 35/55 (4) 34/42 (5) 29/34 (6) 26/34 (7) 26/63	(1) 42/47 (2) 39/60 (3) 41/55 (4) 35/42 (5) 32/34 (6) 31/34 (7) 26/63	No data	(1) 26/47 (2) 18/60 (3) 24/55 (4) 25/42 (5) 27/34 (6) 30/34 (7) 11/63	No data	No data	At 24 h: (1) 2/47 (2) 21/60 (3) 12/55 (4) 5/42 (5) 2/34 (6) 1/34 (7) 22/63
Diener 1999	(1) Sumatriptan 6 mg, n = 114 (2) Intravenous acetylsalicylic acid lysinate 1.8 g, n = 119 (3) Placebo, n = 42	(1) 84/114 (2) 71/119 (3) 8/42	(1) 104/114 (2) 88/119 (3) 10/42	No data	(1) 87/114 (2) 52/119 (3) 6/42	No data	No data	At 24 h: (1) 2/114 (2) 5/119 (3) 7/42
Diener 2001	(1) Sumatriptan 6 mg, n = 317 (2) Alniditan 1.4 mg, n = 309 (3) Alniditan 1.8 mg, n = 141 (4) Placebo, n = 157 (156 for efficacy)	(1) 250/317 (2) 231/309 (3) 114/141 (4) 50/156	(1) 276/317 (2) 250/309 (3) 120/141 (4) 59/156	No data	(1) 209/317 (2) 174/309 (3) 87/141 (4) 22/156	No data	No data	At 24 h: (1) 155/317 (2) 142/309 (3) 65/141 (4) 123/156
Facchinetti 1995	(1) Sumatriptan 6 mg, n = 115 (77 for first dose efficacy with moderate or severe baseline pain intensity) (2) Placebo, n = 111 (92 for first dose efficacy with moderate or severe baseline pain intensity)	(1) 54/77 (2) 20/92	(1) 56/77 (2) 27/92	(1) 25/77 (2) 9/92	(1) 40/77 (2) 12/92	No data	No data	At 2 h: (1) 18/77 (2) 52/92
Ferrari 1991	(1) Sumatriptan 6 mg, n = 423 (422 for efficacy) (2) Sumatriptan 8 mg, n = 110 (109 for efficacy) (3) Placebo, n = 106 (105 for efficacy)	(1) 308/422 (2) 86/109 (3) 26/106	No data	(1) 186/422 (2) 55/109 (3) 8/106	No data	No data	No data	No data
Gross 1994	(1) Sumatriptan 6 mg, n = 60 (48 with moderate or severe baseline pain intensity) (2) Placebo, n = 26 (18 with moderate or severe baseline pain intensity)	(1) 42/48 (2) 2/18	No data	No data	No data	No data	No data	No data
Henry 1993	(1) Sumatriptan 6 mg, n = 37 (2) Placebo, n = 39	(1) 22/37 (2) 8/39	No data	(1) 12/37 (2) 4/39	No data	No data	No data	No data
Jensen 1995	(1) Sumatriptan 6 mg, n = 117 attacks (108 for cross‐over efficacy analysis) (2) Placebo, n = 109 attacks (108 for cross‐over efficacy analysis)	(1) 66/108 (2) 6/108	(1) 73/108 (2) 11/108	(1) 33/108 (2) 1/108	No data	No data	No data	At 2 h: (1) 24/108 (2) 81/108
Mathew 1992	(1) Sumatriptan 1 mg, n = 30 (2) Sumatriptan 2 mg, n = 30 (3) Sumatriptan 3 mg, n = 30 (4) Sumatriptan 4 mg, n = 30 (5) Sumatriptan 6 mg, n = 30 (6) Sumatriptan 8 mg, n = 30 (7) Placebo, n = 62	(1) 13/30 (2) 17/30 (3) 17/30 (4) 15/30 (5) 22/30 (6) 24/30 (7) 15/62	(1) 12/30 (2) 14/30 (3) 17/30 (4) 18/30 (5) 21/30 (6) 26/30 (7) 14/62	(1) 4/30 (2) 1/30 (3) 7/30 (4) 5/30 (5) 12/30 (6) 10/30 (7) 2/62	(1) 6/30 (2) 3/30 (3) 8/30 (4) 10/30 (5) 18/30 (6) 16/30 (7) 2/62	No data	No data	At 4 h: (1) 19/30 (2) 15/30 (3) 14/30 (4) 13/30 (5) 10/30 (6) 10/30 (7) 48/62
Mushet 1996	Study 1 (1) Sumatriptan 6 mg, n = 40 (2) Placebo, n = 39 Study 2 (1) Sumatriptan 6 mg, n = 40 (2) Placebo, n = 39	Study 1 (1) 28/40 (2) 10/40 Study 2 (1) 30/39 (2) 12/39	Study 1 (1) 29/40 (2) 11/40 Study 2 (1) 31/39 (2) 14/39	Study 1 (1) 12/40 (2) 0/40 Study 2 (1) 16/39 (2) 2/39	Study 1 (1) 24/40 (2) 4/40 Study 2: (1) 22/39 (2) 5/39	No data	No data	No data
Pfaffenrath 1991	(1) Sumatriptan 6 mg, n = 155 (147 with moderate or severe baseline pain intensity) (2) Placebo, n = 80 (69 with moderate or severe baseline pain intensity)	(1) 99/147 (2) 17/69	No data	(1) 40/147 (2) 3/69	No data	No data	No data	No data
Russell 1994	(1) Sumatriptan 6 mg, n = 209 (2) Placebo, n = 209	No data	No data	No data	No data	No data	No data	No data
S2BL99	(1) Sumatriptan 6 mg, n = 125 (122 with moderate or severe baseline pain intensity for attack 1) (2) Oral ASA 1000 mg + MCP 10 mg, n = 130 (125 with moderate or severe baseline pain intensity for attack 1)	1st attack: (1) 87/122 (2) 57/125	1st attack: (1) 99/122 (2) 79/125	1st attack: (1) 55/122 (2) 26/125	1st attack: (1) 75/122 (2) 46/125	No data	No data	1st attack, up to 24 h: (1) 27/125 (2) 45/130
S2BM03	(1) Sumatriptan 6 mg (+ placebo at 4 h), n = 106 (90 for cross‐over efficacy analysis, of which 87 had moderate or severe baseline pain intensity) (2) Placebo (+ sumatriptan 6 mg at 4 h), n = 106 (90 for cross‐over efficacy analysis, of which 81 had moderate or severe baseline pain intensity)	(1) 64/87 (2) 7/81	(1) 72/87 (2) 8/81	(1) 41/87 (2) 1/81	(1) 56/87 (2) 3/81	No data	No data	No data
S2BS78	(1) Sumatriptan 6 mg, n = 236 (2) Placebo, n = 117	No data	No data	No data	No data	No data	No data	No data
Sang 2004	(1) Sumatriptan 6 mg, n = 15 (2) Intravenous LY293558 1.2 mg/kg, n = 13 (3) Placebo, n = 16 (15 with moderate or severe baseline pain intensity)	(1) 11/15 (2) 9/13 (3) 2/15	(1) 13/15 (2) 9/13 (3) 4/15	(1) 4/15 (2) 4/13 (3) 1/15	(1) 9/15 (2) 7/13 (3) 1/15	No data	No data	At 2 h: (1) 2/15 (2) 4/13 (3) 14/16
Schulman 2000	(1) Sumatriptan 6 mg, n = 79 (76 for efficacy) (2) Placebo, n = 40	(1) 48/76 (2) 13/40	No data	No data	No data	No data	No data	At 24 h: (1) 4/76 (2) 4/40
SUM40286	(1) Sumatriptan 6 mg, n = 146 (145 for efficacy) (2) Placebo, n = 153 (152 for efficacy)	(1) 95/145 (2) 53/152	(1) 104/145 (2) 62/152	(1) 49/145 (2) 17/152	(1) 70/145 (2) 28/152	No data	(1) 47/145 (2) 22/152	No data
SUM40287	(1) Sumatriptan 6 mg, n = 149 (148 for efficacy) (2) Placebo, n = 139	(1) 105/148 (2) 47/139	(1) 114/148 (2) 44/139	(1) 64/148 (2) 9/139	(1) 84/148 (2) 26/139	No data	(1) 51/148 (2) 21/139	No data
Thomson 1993	(1) Sumatriptan 4 mg, n = 28 (2) Placebo, n = 23 (22 for efficacy)	No data	No data	No data	No data	No data	No data	No data
Touchon 1996	(1) Sumatriptan 6 mg, n = 278 (145 treated first attack, 266 in cross‐over analysis) (2) DHE nasal spray 1 mg, n = 277 (144 treated first attack, 266 in cross‐over analysis)	(1) 189/266 (2) 90/266	(1) 215/266 (2) 138/266	(1) 125/266 (2) 35/266	(1) 176/266 (2) 82/266	(1) 144/266 (2) 104/266	No data	No data
Visser 1992	(1) Sumatriptan 1 mg, n = 170 (2) Sumatriptan 2 mg, n = 171 (3) Sumatriptan 3 mg, n = 172 (4) Placebo, n = 172	No data	No data	No data	No data	No data	No data	No data
Wendt 2006	(1) Sumatriptan 4 mg, n = 384 (381 with moderate or severe baseline pain intensity) (2) Placebo, n = 193 (191 with moderate or severe baseline pain intensity)	(1) 256/381 (2) 49/191	(1) 268/381 (2) 42/191	(1) 129/381 (2) 14/191	(1) 191/381 (2) 21/191	No data	No data	At 24 h: (1) 84/384 (2) 86/193
Winner 1996	(1) Sumatriptan 6 mg, n = 158 (150 for efficacy) (2) Subcutaneous dihydroergotamine (DHE) mesylate 1 mg, n = 152 (145 for efficacy)	(1) 117/150 (2) 82/145	(1) 128/150 (2) 106/145	No data	No data	No data	No data	No data
Winner 2006	Study 1 (1) Sumatriptan 6 mg, n = 146 (145 for efficacy, 144 with moderate or severe baseline pain intensity) (2) Placebo, n = 153 (152 for efficacy, 151 with moderate or severe baseline pain intensity) Study 2 (1) Sumatriptan 6 mg, n = 149 (148 for efficacy) (2) Placebo, n = 139	Pooled results for Study 1 and Study 2 (1) 192/292 (2) 95/290	Study 1 (1) 103/144 (2) 61/151 Study 2 (1) 114/148 (2) 44/139	No data	Study 1 (1) 70/144 (2) 28/151 Study 2 (1) 84/148 (2) 26/139	No data	Study 1 (1) 47/144 (2) 22/151 Study 2 (1) 51/148 (2) 21/139	No data