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Representative synovial tissue before and after specific CC chemokine receptor (CCR)1 blockade for 14 days in a patient with rheumatoid arthritis (haematoxylin–eosin staining; original magnification × 400). After active treatment there was a marked reduction in synovial cellularity, which was not observed in patients who received placebo. The reduction in cell infiltration was due to a specific decrease in CCR1-positive cells [29].
