Figure 1.LMNA splicing products involved in diseases and prelamin A forms accumulated in laminopathies. (A) Genomic organization and protein domain structure of the LMNA splicing products involved in laminopathies: prelamin A, progerin, and lamin C. (B) Prelamin A processing steps. The four different prelamin A forms are represented. Below each prelamin A processing intermediate structure, the disease(s) showing accumulation of that form are indicated in parentheses. The processing steps of progerin seem to be the same as for prelamin A and are not represented in this scheme. Question marks indicate possible accumulation in laminopathies.