Table 2. Associations of maternal characteristics and cervical DNA methylation, ELEMENT birth cohort, Mexico City.
| PTGER2 β^ in % 5mC (95% CI) | LINE 1-HS β^ in % 5mC (95% CI) | ||||
|---|---|---|---|---|---|
| Maternal characteristics | |||||
| Model 1 | Model 2 | Model 1 | Model 2 | ||
| Maternal age (years) | |||||
| < 20 | 5.4 (-8.2, 19.0) | 3.2 (-9.2, 15.6) | -1.6 (-5.3, 2.1) | -0.9 (-4.1, 2.3) | |
| 20- < 35 | ref. | ref. | ref. | ref. | |
| ≥ 35 | 3.8 (-9.1, 16.7) | 6.5 (-5.3, 18.3) | -0.7 (-3.8, 2.4) | -2.1 (-4.8, 0.4) | |
| Maternal pre-pregnancy BMI per kg/m2 | 0.7 (-0.2, 1.6) | 0.6 (-0.2, 1.5) | -0.2 (-0.5, 0.0) | -0.2 (-0.4, 0.0) | |
| Primiparous (vs. multiparous) | -4.1 (-11.8, 3.5) | -6.0 (-13.0, 1.0) | 1.7 (-0.3, 3.7) | 2.3 (0.5, 4.1) | |
| Maternal Education (> = 12 y vs. less) | -3.4 (-11.6, 4.9) | -5.9 (-13.6, 1.7) | -0.5 (-2.7, 1.8) | 0.4 (-1.6, 2.3) | |
| Smoking exposure within the home (vs. not) | -2.2 (-10.3, 6.0) | 0.8 (-6.8, 8.4) | -1.6 (-3.7, 0.9) | -2.5 (-4.4, -0.6) | |
| Smoking prior to pregnancy (vs. never) | -6.8 (-14.6, 1.1) | -4.3 (-11.5, 3.0) | 1.6 (-0.5, 3.7) | 0.8 (-1.1, 2.6) | |
| Maternal second trimester blood lead per μg/dl | 0.5 (-1.6, 2.6) | 0.3 (-1.6, 2.2) | 0.0 (-0.6, 0.5) | 0.1 (-0.4, 0.5) | |
| Pap smear inflammation (vs. not) | -13.5 (-20.6, -6.4) | 4.5 (2.7, 6.3) | |||
PTGER2 prostaglandin E receptor 2 (subtype EP2); LINE 1-HS long interspersed nuclear element-1 Homo sapiens-specific. PTGER2 models include 73 participants; LINE 1-HS models include 75 participants. ^β coefficients obtained from linear regression models inclusive of all variables listed.