Table 2.

Reported adverse events

	All grades, no. (%)	Grade 3 or 4
Anemia	39 (21)	1 (<1)
Peripheral edema	37 (20)	0
Fatigue	36 (19)	1 (<1)
Nausea	30 (16)	0
Dyspnea	23 (12)	1 (<1)
Neutropenia	22 (12)	2 (1)
Hypertension	21 (11)	2 (1)
Hypokalemia	19 (10)	3 (2)
Hypercholesterolemia	13 (7)	0
ALT elevation	12 (6)	1 (<1)
AST elevation	11 (6)	0
Constipation	10 (5)	0
Diarrhea	9 (5)	0
Emesis	9 (5)	0
Thrombocyopenia	2 (1)	0

ALT: alanine aminotransferase; AST: aspartate aminotransferase.