Table 1.
Patient and Tumor Characteristics (n = 127)
| Characteristic | Temsirolimus (n = 93) |
Everolimus (n = 34) |
|---|---|---|
| Median Age at Initiation of Therapy, Years | 61 | 62 |
| Median Performance Score (KPS) | 80% | 90% |
| Sex | ||
| Male | 66 (71) | 26 (76) |
| Female | 27 (29) | 8 (24) |
| Pathology | ||
| Clear Cell | 48 (52) | 17 (50) |
| Non-Clear Cell | 37 (40) | 14 (41) |
| Unknown | 8 (9) | 3 (9) |
| Sarcomatoid Features | ||
| Yes | 13 (14) | 9 (26) |
| No | 67 (72) | 21 (62) |
| Unknown | 13 (14) | 4 (12) |
| Previous Nephrectomy | ||
| Yes | 58 (62) | 28 (82) |
| No | 35 (38) | 6 (18) |
| Number of Metastases >1 | 78 (84) | 26 (76) |
| Metastatic Site | ||
| Lung | 61 (66) | 18 (53) |
| Lymph node | 59 (63) | 19 (56) |
| Bone | 38 (41) | 10 (29) |
| Liver | 26 (28) | 8 (24) |
| Brain | 8 (9) | 2 (6) |
| IMDC Risk Groupa | ||
| Favorable | 6 (6) | 5 (15) |
| Intermediate | 25 (27) | 10 (29) |
| Poor | 42 (45) | 7 (21) |
| Unknown | 20 (22) | 12 (35) |
Data are presented as n (%) except where otherwise noted.
Abbreviations: IMDC = International Metastatic Renal Cell Carcinoma Database Consortium; KPS = Karnofsky performance status.
a
IMDC poor prognosis risk factors include absence of nephrectomy, KPS < 70%, hemoglobin level below normal, high serum corrected calcium, high absolute neutrophil count, and thrombocytosis.