Figure 6. Effect of OA on the respiration of isolated mitochondria from the liver.

Mitochondria from rat liver were isolated and the effects of OA/BBR were determined in the presence of excess ADP (2.4 mM), using substrate combinations targeting either Complex I (5 mM pyruvate plus 2 mM malate) or Complex II (10 mM succinate plus 4 µM rotenone) of the respiratory chain. Data are mean ± SE. *p<0.05, **p<0.01 vs. vehicle control (0 µM). n = 3 per group.