Table 1. Metabolic responses during and post OA administration in T2D mice induced by HF-STZ.

	During OA treatment			Post-OA treatment
	CH	T2D	T2D-OA	CH	T2D	T2D-OA
Body weight (g)	29.8±0.5	27.7±0.3	25.3±1.4**†	31.9±0.8	30.2±0.7	29.3±0.7*
Caloric intake (kcal/mouse/day)	13.6±0.7	12.2±0.6	10.9±0.7	10.9±0.5	12.2±1.2	14.1±1.3
Blood glucose (mM)	9.6±0.2	21.3±0.4**	11.1±1.2††	10.0±0.5	26.3±1.3**	14.8±2.3††
ipGTT AUC (mM ×90 min)	1442±38	2902±71**	2045±171**††	1494±71	2609±131**	1838±98**††
Blood insulin (pg/ml)	361±37	306±45	240±21**	367±29	301±63	212±12**
Blood insulin (5–60 min, pg/ml)	417±37	181±13**	241±28**†	441±36	191±18**	280±37**
Plasma triglyceride (mM)	1.1±0.1	2.1±0.2**	1.3±0.2††	1.6±0.1	2.0±0.4*	1.8±0.1
Liver triglyceride (µmol/g)	7.6±0.9	16.8±0.9**	11.3±0.6*††	12.9±0.9	18.9±0.9**	24.9±2.3**

During treatment: 4-week administration of oleanolic acid (OA, 100 mg/kg/day in HF diet). Parameters were measured within the last 2 weeks of treatment. Post-treatment: 2-week administration of OA (100 mg/kg/day in HF diet) followed by feeding with an OA-free HF diet for 4 weeks. Parameters were measured within the last 2 weeks of the post-treatment period. CH, chow fed mice (normal control); T2D, HF-fed mice with STZ injections (untreated T2D); T2D-OA, T2D with OA treatment. AUC, area under the curve of blood glucose levels during an ipGTT. Data are shown as means ± SE. * p<0.05, ** p<0.01 vs. corresponding CH; † p<0.05, †† p<0.01 vs. corresponding T2D. n = 7–8 mice per group.