TABLE V.
GENE-GREEN TEA INTERACTIONS BETWEEN GSTM1, GSTT1, GSTP1, P53 CODON 72 AND GREEN TEA DRINKING ON THE RISK OF STOMACH CANCER
| Genes | Green tea drinking |
Cases | Controls | Crude OR (95% CI) |
Adjusted OR (95% CI)1 |
|---|---|---|---|---|---|
| n | n | ||||
| GSTM1 | |||||
| Normal | Yes | 20 | 67 | 1 | 1 |
| Normal | Yes | 40 | 103 | 1.30 (0.70–2.42) | 0.88 (0.40–1.93) |
| Null | No | 43 | 82 | 1.76 (0.94–3.27) | 1.31 (0.56–3.08) |
| Null | No | 81 | 124 | 2.19 (1.23–3.88) | 1.64 (0.76–3.56) |
| OR for interaction | 0.96 (0.44–2.07) | 1.43 (0.53–3.83) | |||
| GSTT1 | |||||
| Normal | Yes | 35 | 82 | 1 | 1 |
| Normal | Yes | 25 | 88 | 0.67 (0.37–1.21) | 0.84 (0.40–1.77) |
| Null | No | 65 | 109 | 1.40 (0.85–2.31) | 1.36 (0.66–2.79) |
| Null | No | 59 | 97 | 1.43 (0.86–2.38) | 1.71 (0.84–3.47) |
| OR for interaction | 1.53 (0.73–3.22) | 1.49 (0.58–3.83) | |||
| GSTP1 | |||||
| Ile/ile or Ile/Val | Yes | 57 | 163 | 1 | 1 |
| Val/Val | Yes | 3 | 6 | 1.43 (0.35~5.91) | 0.79 (0.34~1.79) |
| Ile/ile or Ile/Val | No | 118 | 202 | 1.67 (1.15~2.44) | 1.43 (0.76~2.69) |
| Val/Val | No | 6 | 5 | 3.43 (1.01~11.67) | 1.69 (0.84~3.38) |
| OR for interaction | 1.44 (0.22~9.26) | 1.25 (0.13~12.17) | |||
| p53 codon 72 | |||||
| Arg/Arg or Arg/Pro | Yes | 39 | 126 | 1 | 1 |
| Pro/Pro Yes | 20 | 41 | 1.58 | (0.83~3.00) | 1.07 (0.48~2.37) |
| Arg/Arg or Arg/Pro | No | 82 | 158 | 1.68 (1.07~2.62) | 1.37 (0.73~2.60) |
| Pro/Pro | No | 41 | 48 | 2.76 (1.59~4.78) | 2.75 (1.28~5.93) |
| OR for interaction | 1.04 (0.46~2.35) | 1.88 (0.68~5.21) | |||
| Multi-genetic Index | |||||
| 0~1 | Yes | 33 | 93 | 1 | 1 |
| 2~4 | Yes | 26 | 74 | 0.99 (0.55~1.80) | 0.82 (0.38~1.74) |
| 0~1 | No | 57 | 119 | 1.35 (0.81~2.24) | 1.08 (0.52~2.22) |
| 2~4 | No | 66 | 86 | 2.16 (1.30~3.60) | 2.03 (0.99~4.15) |
| OR for interaction | 1.62 (0.77~3.42) | 2.31 (0.88~6.03) |
1
Adjusted on age (continuous variable), gender (male or female), education (continuous), income (continuous variable), body mass index (continuous variable), pack-year of smoking (continuous), alcohol drinking (1, never; 2, seldom; 3, often; 4, every day), very hot food eating habit, H. pylori infection (CagA + or −), stomach disease history and family history of stomach cancer.