Table 1.
Patient characteristics
| Febuxostat | Allopurinol | Pvalue | |
|---|---|---|---|
| No. of patients | 38 | 39 | |
| Agea | 62.5 (26–83) | 64 (25–79) | 0.46 |
| Body weightb, kg | 61 ± 12 | 53 ± 12 | 0.0051 |
| Diseasec, n | 0.24 | ||
| Acute myeloid leukemia | 10 | 10 | |
| Acute lymphoblastic leukemia | 0 | 4 | |
| Non-Hodgkin lymphoma | |||
| aggressive B-cell | 6 | 10 | |
| indolent B-cell | 11 | 9 | |
| T-cell | 4 | 3 | |
| Others | 7 | 3 | |
| Serum creatinineb, mg/dL | 0.90 ± 0.39 | 0.76 ± 0.30 | 0.071 |
| Renal dysfunctionc, n (%) | 0.0073 | ||
| Yes | 14 (37%) | 4 (10%) | |
| TLS riskc, n | 0.30 | ||
| Low | 18 | 12 | |
| Intermediate | 18 | 24 | |
| High | 2 | 3 | |
| Serum LDHb, IU/L | 395 ± 360 | 468 ± 542 | 0.49 |
| Serum uric acidb, mg/dL | |||
| Overall | 5.8 ± 2.3 | 5.4 ± 1.6 | 0.41 |
| Patients not receiving rasburicase | 5.6 ± 2.1 | 5.4 ± 1.6 | 0.73 |
aMedian (range). P values were analyzed by Mann–Whitney U test.
bMean ± SD. P values were analyzed by t-test.
cFischer’s exact test were used for categorical variables.