Figure 1.

AUUUA- motifs in mouse BDNF 3’ UTR and their conservation among vertebrates. a. Schematic diagram of BDNF mRNA products with long (BDNF-L) and short (BDNF-S) 3’UTRs. AUUUA sequences, often serving as ARE-BP binding motifs within AU-rich elements (AREs) are indicated with black triangles, AREs UAUUUAU are indicated with up arrowheads, black box denotes BDNF coding sequence (Source: AREsite and AREscore). mRNA-s transcribed from luciferase reporter constructs (grey boxes) containing BDNF-L, BDNF-S, U1, U2 and ARE-rich fragment from TNFα 3’UTR. The positions of U1 and U2 (see below) are indicated above Luc-BDNF-S. b. Scheme depicting conservation of AUUUA sequences among vertebrates. UAUUUAU motifs are underlined and in bold.