Fig. 1. .

Mechanisms for the progression of peritoneal fibrosis in animal models. A variety of factors or stimuli, such as chlorhexidine gluconate (CG) or methylglyoxal (MGO), are thought to be involved in peritoneal fibrosis. They lead to inflammation and angiogenesis in the peritoneum. The subsequent myofibroblast proliferation by several cytokines and growth factors, and the accompanying accumulation of extracellular matrix in the peritoneum, are the key events that lead to peritoneal fibrosis.