Table 1.
Characteristics of Patients With Early-Stage Breast Cancer Younger Than Age 65 Years According to Chemotherapy Regimen
| Variable | Total (N = 9,327) |
TC (n = 1,060) |
AC (n = 2,889) |
TAC (n = 1,516) |
AC + T (n = 894) |
ddAC + P (n = 2,657) |
AC + wP (n = 311) |
P | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | ||
| Age, years | < .001 | ||||||||||||||
| Range | 23-64 | 26-64 | 24-64 | 27-64 | 27-64 | 23-64 | 30-64 | ||||||||
| Mean | 51 ± 8 | 52 ± 7 | 52 ± 8 | 50 ± 8 | 51 ± 8 | 50 ± 8 | 51 ± 8 | ||||||||
| Median | 52 | 52 | 52 | 51 | 52 | 51 | 52 | ||||||||
| < 35 | 271 | 2.9 | 18 | 1.7 | 65 | 2.2 | 57 | 3.8 | 18 | 2.0 | 102 | 3.8 | 11 | 3.5 | |
| 35-44 | 1,734 | 18.6 | 176 | 16.6 | 451 | 15.6 | 310 | 20.4 | 169 | 18.9 | 561 | 21.1 | 67 | 21.5 | |
| 45-54 | 3,929 | 42.1 | 436 | 41.1 | 1,240 | 42.9 | 673 | 44.4 | 360 | 40.3 | 1,111 | 41.8 | 109 | 35.0 | |
| 55-64 | 3,393 | 36.4 | 430 | 40.6 | 1,133 | 39.2 | 476 | 31.4 | 347 | 38.8 | 883 | 33.2 | 124 | 39.9 | |
| Region* | < .001 | ||||||||||||||
| Northeast | 694 | 7.4 | 84 | 7.9 | 200 | 6.9 | 89 | 5.9 | 32 | 3.6 | 275 | 10.4 | 14 | 4.5 | |
| North Central | 2,454 | 26.3 | 234 | 22.1 | 796 | 27.6 | 309 | 20.4 | 193 | 21.6 | 829 | 31.2 | 93 | 29.9 | |
| South | 4,689 | 50.3 | 578 | 54.5 | 1,412 | 48.9 | 884 | 58.3 | 516 | 57.7 | 1,130 | 42.5 | 169 | 54.3 | |
| West | 1,448 | 15.5 | 163 | 15.4 | 470 | 16.3 | 229 | 15.1 | 148 | 16.6 | 406 | 15.3 | 32 | 10.3 | |
| Surgery | < .001 | ||||||||||||||
| Lumpectomy | 4,701 | 50.4 | 579 | 54.6 | 1,754 | 60.7 | 631 | 41.6 | 369 | 41.3 | 1,234 | 46.4 | 134 | 43.1 | |
| Mastectomy | 4,529 | 48.6 | 470 | 44.3 | 1,099 | 38.0 | 871 | 57.5 | 515 | 57.6 | 1,397 | 52.6 | 177 | 56.9 | |
| Axillary LND | 97 | 1.0 | 11 | 1.0 | 36 | 1.2 | 14 | 0.9 | ≤ 10 | 26 | 1.0 | ≤ 10 | |||
| Hormone therapy† | 5,018 | 53.8 | 607 | 57.3 | 1,592 | 55.1 | 815 | 53.8 | 432 | 48.3 | 1,431 | 53.9 | 141 | 45.3 | < .001 |
| G-CSF primary prophylaxis | 4,701 | 50.4 | 518 | 48.9 | 597 | 20.7 | 1,204 | 79.4 | 220 | 24.6 | ,2089 | 78.6 | 73 | 23.5 | < .001 |
| Hospitalization in previous 90 days‡ | 394 | 4.2 | 49 | 4.6 | 105 | 3.6 | 76 | 5.0 | 46 | 5.1 | 107 | 4.0 | 11 | 3.5 | .172 |
Abbreviations: AC, doxorubicin and cyclophosphamide; AC + T, doxorubicin and cyclophosphamide followed or preceded by docetaxel; AC + wP, doxorubicin and cyclophosphamide followed or preceded by weekly paclitaxel; ddAC + P, dose-dense doxorubicin and cyclophosphamide followed or preceded by paclitaxel; G-CSF, granulocyte colony-stimulating factor; LND, lymph node dissection; TAC, docetaxel, doxorubicin, and cyclophosphamide; TC, docetaxel and cyclophosphamide.
*
Unknown in 42 patients.
†
Received tamoxifen or an aromatase inhibitor.
‡
Occurring within 90 days before initiation of chemotherapy.