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. 2014 Sep 8;15:106. doi: 10.1186/1471-2202-15-106

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© Magon et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Mean cortical thickness in proximity of juxtacortical lesions computed by the two analysis strategies over 6 years of follow-up in MS patients. a) Three ROIs were drawn in order to evaluate how the approach with lesion filling performs in the presence of juxtacortical lesions: L0 represents the lesion and its border, L1 includes a two voxels rim surrounding L0 and may be consider as a transition zone between lesion and normal-appearing tissue. L2 includes the two voxels rim surrounding L1 and represents normal-appearing tissue. b) mean cortical thickness (CTh) and standard error for the defined ROIs. BL: baseline; Y3: follow-up after 3 years; Y6: follow-up after 6 years.