Table 1.

Adipogenic and diabetogenic gene variants identified in outcross populations of obese mice

Gene symbol	Gene name/function	Variant	Trait associated with variant	Obesity induced by	Strains with variant	Reference
Pctp	Phosphatidylcholine transfer protein	1 amino acid substitution, reduced activity	Serum insulin	NZO background	NZO, NZB	Pan et al. (2006a, b), Ersoy et al. (2013)
Tbc1d1	Rab-GTPase activating protein	Deletion/frameshift and truncation of protein	Accumulation of body fat	NZO background	SJL	Chad et al. (2008)
Zfp69	Zinc finger domain transcription factor	Premature polyadenylation caused by retrotransposon	Plasma glucose and insulin, hepatic fat	NZO background	NZO, C57BL/6J	Scherneck et al. (2009)
Ifi202b	Interferon-activated 202b	Deletion of promoter and exon 1, no expression	11ß-HSD expression, adiposity	NZO background	C57BL/6J	Vogel et al. (2012)
Lepr	Leptin receptor	4 coding SNPs (V541I, V651I, A720T, T1044I)	Food intake	NZO background	NZO, NZB	Igel et al. (1997), Kluge et al. (2000)
Abcg1	ATP-binding cassette transporter G1	Insertion of LXR element in intron 2, increased expression of Abcg1	Accumulation of body fat	NZO background	NZO, NZB	Buchmann et al. (2007)
Nmur2	Neuromedin U receptor 2	2 coding SNPs (V190 M, I202 M), reduced activity	Food intake	NZO background	NZO, NZB	Schmolz et al. (2007)
Sorcs1	Sortilin-related VPS10 domain containing receptor	Reduced expression and 3 coding SNPs (T52I, S1140F, S1150P)	beta-cell disruption, development of islet vasculature	ob/ob	BTBR T+tf/J	Clee et al. (2006)
Lisch-like	Similar to Lisch7/Lsr (lipolysis stimulated receptor).	Reduced expression and 2 coding SNPs (T587A, A647 V)	beta-cell disruption	ob/ob	DBA/2 J	Dokmanovic-Chouinard et al. (2008)
Tomosyn-2	Syntaxin-binding protein 5-like	Increased expression and coding SNP (S912L)	Reduced insulin secretion	ob/ob	BTBR T+tf/J	Bhatnagar et al. (2011)
Tsc2	Tuberous sclerosis complex 2	Coding SNP, reduced activity inhibiting lipogenesis	Hepatic steatosis	ob/ob	BTBR T+tf/J	Wang et al. (2012)
App	Amyloid precursor protein	Increased expression in beta cells	Insulin secretion	ob/ob	BTBR T+tf/J	Tu et al. (2012)
Ube2l6	Ubiquitin-conjugating enzyme E2L8	Coding SNP (D29Y) and suppressed expression	Fat mass, reduced lipid synthesis	ob/ob	BALB/c	Marcelin et al. (2013)
Slc35b4	Solute carrier family 35 member B4, transporter of xylose in Golgi	Increased expression in liver	Reduced production of glucose, increased insulin sensitivity	Diet	A/J	Yazbek et al. (2011)
Apcs	Amyloid P component	Increased expression in liver	Fasting glucose	Diet	C3H/HeJ	Li et al. (2012)
Nnt	Nicotinamide nucleotide transhydrogenase	Deletion of 5 exons, absence of protein	Reduced glucose-stimulated insulin secretion	No obesity	C57BL/6J	Toye et al. (2005)