1. Comparative efficacy and acceptability of milnacipran for acute major depression.

	MTM (Cipriani 2009a)	Current review
	OR (95%CI)	OR (95%CI)	Relative ratio of ORsa
Efficacy (response rate)
Fluvoxamine	1.03 (0.73‐1.47)	1.76 (0.81‐3.83)	0.59
Fluoxetine	1.01 (0.76‐1.35)	0.93 (0.55‐1.58)	1.09
Paroxetine	1.00 (0.74‐1.33)	0.93 (0.59‐1.47)	1.08
Sertraline	0.81 (0.60‐1.11)	3.83 (0.90‐16.26)	0.21
Acceptability (total dropout rate)
Fluvoxamine	0.85 (0.57‐1.32)	0.82 (0.36‐1.86)b	1.03
Fluoxetine	1.03 (0.76‐1.45)	1.02 (0.71‐1.46)	1.01
Paroxetine	0.94 (0.68‐1.31)	0.88 (0.50‐1.54)	1.07
Sertraline	1.17 (0.84‐1.72)	1.70 (0.57‐5.05)b	0.69

For efficacy, OR higher than 1 favour milnacipran. For acceptability, OR lower than 1 favour milnacipran .

^aORs of the current review as reference.

^bTwo trials comparing milnacipran with fluvoxamine (Annseau 1991c) and with sertraline (Shinkai 2004) were excluded because these 4‐week trials were not included in MTM.

Abbreviations: MTM=multiple‐treatments meta‐analysis, OR=odds ratio, CI=confidence interval