Comparison 1. Response at acute phase (6‐12 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Milnacipran vs TCAs	4	537	Odds Ratio (M‐H, Random, 95% CI)	0.87 [0.59, 1.30]
1.1 Milnacipran vs Imipramine	3	430	Odds Ratio (M‐H, Random, 95% CI)	1.05 [0.71, 1.54]
1.2 Milancipran vs Clomipramine	1	107	Odds Ratio (M‐H, Random, 95% CI)	0.45 [0.21, 0.98]
2 Milnacipran vs SSRIs	6	1028	Odds Ratio (M‐H, Random, 95% CI)	1.11 [0.76, 1.64]
2.1 Milnacipran vs Fluvoxamine	1	113	Odds Ratio (M‐H, Random, 95% CI)	1.76 [0.81, 3.83]
2.2 Milnacipran vs Fluoxetine	3	560	Odds Ratio (M‐H, Random, 95% CI)	0.93 [0.55, 1.58]
2.3 Milnacipran vs Paroxetine	1	302	Odds Ratio (M‐H, Random, 95% CI)	0.93 [0.59, 1.47]
2.4 Milnacipran vs Sertraline	1	53	Odds Ratio (M‐H, Random, 95% CI)	3.83 [0.90, 16.26]