Comparison 2. Response at early phase (1‐4 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Milnacipran vs TCAs	6	802	Odds Ratio (M‐H, Random, 95% CI)	0.83 [0.58, 1.20]
1.1 Milancipran vs Imipramine	3	462	Odds Ratio (M‐H, Random, 95% CI)	1.11 [0.73, 1.69]
1.2 Milnacipran vs Clomipramine	1	107	Odds Ratio (M‐H, Random, 95% CI)	0.46 [0.17, 1.24]
1.3 Milnacipran vs Amitriptyline	2	233	Odds Ratio (M‐H, Random, 95% CI)	0.62 [0.35, 1.08]
2 Milancipran vs SSRIs	6	953	Odds Ratio (M‐H, Random, 95% CI)	1.30 [0.97, 1.73]
2.1 Milnacipran vs Fluvoxamine	2	240	Odds Ratio (M‐H, Random, 95% CI)	1.54 [0.87, 2.72]
2.2 Milnacipran vs Fluoxetine	2	370	Odds Ratio (M‐H, Random, 95% CI)	1.49 [0.93, 2.37]
2.3 Milnacipran vs Paroxetine	2	343	Odds Ratio (M‐H, Random, 95% CI)	0.99 [0.61, 1.60]
3 Milnacipran vs Heterocyclics	1	179	Odds Ratio (M‐H, Random, 95% CI)	1.10 [0.54, 2.23]
3.1 Milancipran vs Mianserin	1	179	Odds Ratio (M‐H, Random, 95% CI)	1.10 [0.54, 2.23]