Comparison 4. Remission at acute phase (6‐12 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Milnacipran vs TCAs	4	537	Odds Ratio (M‐H, Random, 95% CI)	0.82 [0.57, 1.19]
1.1 Milnacipran vs Imipramine	3	430	Odds Ratio (M‐H, Random, 95% CI)	0.94 [0.62, 1.41]
1.2 Milnacipran vs Clomipramine	1	107	Odds Ratio (M‐H, Random, 95% CI)	0.43 [0.17, 1.07]
2 Milnacipran vs SSRIs	6	1028	Odds Ratio (M‐H, Random, 95% CI)	0.98 [0.73, 1.32]
2.1 Milnacipran vs Fluvoxamine	1	113	Odds Ratio (M‐H, Random, 95% CI)	1.48 [0.66, 3.30]
2.2 Milnacipran vs Fluoxetine	3	560	Odds Ratio (M‐H, Random, 95% CI)	0.91 [0.56, 1.46]
2.3 Milnacipran vs Paroxetine	1	302	Odds Ratio (M‐H, Random, 95% CI)	0.92 [0.57, 1.49]
2.4 Milnacipran vs Sertraline	1	53	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]