Comparison 5. Remission at early phase (1‐4 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Milnacipran vs TCAs	6	802	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.56, 1.40]
1.1 Milnacipran vs Imipramine	3	462	Odds Ratio (M‐H, Random, 95% CI)	1.03 [0.59, 1.79]
1.2 Milnacipran vs Clomipramine	1	107	Odds Ratio (M‐H, Random, 95% CI)	0.69 [0.11, 4.33]
1.3 Milnacipran vs Amitriptyline	2	233	Odds Ratio (M‐H, Random, 95% CI)	0.62 [0.25, 1.54]
2 Milnacipran vs SSRIs	6	953	Odds Ratio (M‐H, Random, 95% CI)	1.28 [0.77, 2.14]
2.1 Milnacipran vs Fluvoxamine	2	240	Odds Ratio (M‐H, Random, 95% CI)	1.36 [0.52, 3.58]
2.2 Milnacipran vs Fluoxetine	2	370	Odds Ratio (M‐H, Random, 95% CI)	1.72 [0.71, 4.17]
2.3 Milnacipran vs Paroxetine	2	343	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.42, 2.17]
3 Milnacipran vs Heterocyclics	1	179	Odds Ratio (M‐H, Random, 95% CI)	1.44 [0.57, 3.67]
3.1 Milnacipran vs Mianserin	1	179	Odds Ratio (M‐H, Random, 95% CI)	1.44 [0.57, 3.67]