Comparison 10. Dropouts due to inefficacy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Milnacipran vs TCAs	7	902	Odds Ratio (M‐H, Random, 95% CI)	1.27 [0.82, 1.99]
1.1 Milnacipran vs Imipramine	4	562	Odds Ratio (M‐H, Random, 95% CI)	1.14 [0.66, 1.95]
1.2 Milnacipran vs Clomipramine	1	107	Odds Ratio (M‐H, Random, 95% CI)	3.04 [0.89, 10.38]
1.3 Milnacipran vs Amitryptyline	2	233	Odds Ratio (M‐H, Random, 95% CI)	1.10 [0.42, 2.90]
2 Milnacipran vs SSRIs	7	1143	Odds Ratio (M‐H, Random, 95% CI)	0.99 [0.66, 1.48]
2.1 Milnacipran vs Fluvoxamine	2	240	Odds Ratio (M‐H, Random, 95% CI)	1.39 [0.53, 3.63]
2.2 Milnacipran vs Fluoxetine	3	560	Odds Ratio (M‐H, Random, 95% CI)	0.84 [0.42, 1.70]
2.3 Millnacipran vs Paroxetine	2	343	Odds Ratio (M‐H, Random, 95% CI)	1.58 [0.55, 4.54]
3 Milnacipran vs Heterocyclics	1	179	Odds Ratio (M‐H, Random, 95% CI)	0.57 [0.22, 1.51]
3.1 Milnacipran vs Mianserin	1	179	Odds Ratio (M‐H, Random, 95% CI)	0.57 [0.22, 1.51]