Comparison 12. Patients with at least some adverse events (Tolerability).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Milnacipran vs TCAs	6	795	Odds Ratio (M‐H, Random, 95% CI)	0.35 [0.24, 0.53]
1.1 Milnacipran vs Imipramine	4	562	Odds Ratio (M‐H, Random, 95% CI)	0.43 [0.28, 0.66]
1.2 Milnacipran vs Amitriptyline	2	233	Odds Ratio (M‐H, Random, 95% CI)	0.23 [0.13, 0.40]
2 Milnacipran vs SSRIs	5	912	Odds Ratio (M‐H, Random, 95% CI)	0.86 [0.55, 1.34]
2.1 Milnacipran vs Fluvoxamine	2	240	Odds Ratio (M‐H, Random, 95% CI)	0.51 [0.28, 0.94]
2.2 Milnacipran vs Fluoxetine	2	370	Odds Ratio (M‐H, Random, 95% CI)	0.90 [0.49, 1.67]
2.3 Milnacipran vs Paroxetine	1	302	Odds Ratio (M‐H, Random, 95% CI)	1.45 [0.87, 2.43]
3 Milnacipran vs Heterocyclics	1	179	Odds Ratio (M‐H, Random, 95% CI)	0.62 [0.34, 1.15]
3.1 Milnacipran vs Mianserin	1	179	Odds Ratio (M‐H, Random, 95% CI)	0.62 [0.34, 1.15]