Comparison 16. Adverse events: Constipation.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Milnacipran vs TCAs	6	795	Odds Ratio (M‐H, Random, 95% CI)	0.62 [0.44, 0.88]
1.1 Milancipran vs Imipramine	4	562	Odds Ratio (M‐H, Random, 95% CI)	0.64 [0.41, 0.98]
1.2 Milnacipran vs Amitriptyline	2	233	Odds Ratio (M‐H, Random, 95% CI)	0.60 [0.34, 1.06]
2 Milancipran vs SSRIs	5	800	Odds Ratio (M‐H, Random, 95% CI)	1.19 [0.69, 2.06]
2.1 Milnacipran vs Fluvoxamine	2	240	Odds Ratio (M‐H, Random, 95% CI)	1.30 [0.28, 6.01]
2.2 Milnacipran vs Fluoxetine	3	560	Odds Ratio (M‐H, Random, 95% CI)	1.43 [0.67, 3.06]
3 Milnacipran vs Heterocyclics	1	179	Odds Ratio (M‐H, Random, 95% CI)	0.27 [0.05, 1.29]
3.1 Milancipran vs Mianserin	1	179	Odds Ratio (M‐H, Random, 95% CI)	0.27 [0.05, 1.29]