Annseau 1989a.

Methods	4 week randomised double blind study.
Participants	Diagnosis: Inpatients with RDC major depressive disorder Male and Female. Threshold of baseline severity: MADRS>=25, CGI<=4, Raskin Scale for Depression>Covi Anxiety Scale Total number of all allocated participants: N=146 Age: mean 48.6 (SD 10.8) y, range 20‐70y.
Interventions	Milnacipran 50/100mg: N=97 (50mg: N=47, 100mg: N=48) Amitriptyline 150mg: N=49 Fixed dosing schedule
Outcomes	Hamilton Depression Rating Scale‐24 item, MADRS,CGI‐I, CGI‐S
Notes	Funding: by industry
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomly assigned". Probably done.
Allocation concealment (selection bias)	Unclear risk	Insufficient information.
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "double‐blind". Probably done.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing primary outcome data.
Selective reporting (reporting bias)	High risk	Did not provide number of participants who dropped out during the study due to side effects.
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists.