Clerc 2001.

Methods	6 week randomised double blind study
Participants	Diagnosis: Outpatients with DSM‐III‐R major depressive episode Male and Female. Threshold of baseline severity: MADRS>=25, Raskin Scale for Depression Total number of all allocated participants: N=113 Age: mean 48.7 (SD 15.1)y for milnacipran, mean 51.2 (SD 12.6)y for fluvoxamine
Interventions	Milnacipran 100mg: N=57 Fluvoxamine 200mg: N=56 Fixed dosing schedule.
Outcomes	Hamilton Depression Rating Scale‐24 item, MADRS,CGI‐I, CGI‐S, CGI‐E
Notes	Funding: by industry
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomised". Probably done.
Allocation concealment (selection bias)	Unclear risk	Insufficient information.
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "double‐blind"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing primary outcome data.
Selective reporting (reporting bias)	Low risk	The study protocol is not available but it is clear that the published reports include all expected outcomes, including those that were pre‐specified.
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists.