Endo 1995.

Methods	4 week randomised double blind study
Participants	Diagnosis: In‐ and Out‐patients with DSM‐III‐R major depressive episode Male and Female. Threshold of baseline severity: Not reported. Total number of all allocated participants: N=179 Age: range 20‐65y
Interventions	Milnacipran 50‐150mg (mean: 68.6mg): N=84 Mianserine 30‐ 60mg : N=95 Flexible dosing schedule.
Outcomes	Hamilton Depression Rating Scale‐21 item, CGI‐I, CPRG
Notes	Funding: by industry Article in Japanese.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomised". Probably done.
Allocation concealment (selection bias)	Low risk	Central allocation used.
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "double‐blind"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing primary outcome data.
Selective reporting (reporting bias)	Low risk	The study protocol is not available but it is clear that the published reports include all expected outcomes, including those that were pre‐specified.
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists.