Lee 2002b.

Methods	6 week randomised open‐label study
Participants	Diagnosis: Outpatients with DSM‐IV major depressive disorder Male and Female. Threshold of baseline severity: HDRS‐17>=17, MADRS>=21 Total number of all allocated participants: N=70 Age: mean 49 (SD 15)y for milnacipran , mean 51 (SD 12)y for fluoxetine; range 17‐70y
Interventions	Milnacipran 100mg: N=39 Fluoxetine 20mg: N=31 Fixed dosing schedule.
Outcomes	Hamilton Depression Rating Scale‐17 item, MADRS, CGI‐I, Covi Anxiety Scale
Notes	Funding: by industry Article in Korean.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomised". Probably done.
Allocation concealment (selection bias)	Unclear risk	Insufficient information.
Blinding (performance bias and detection bias) All outcomes	High risk	Open‐label study
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing primary outcome data.
Selective reporting (reporting bias)	Unclear risk	Insufficient information.
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists.