Leinonen 1997.

Methods	26 week randomised double blind study
Participants	Diagnosis: In‐ and Out‐patients with DSM‐III‐R major depressive episode Male and Female. Threshold of baseline severity: HDRS‐17>=18, CGI>=moderately ill Total number of all allocated participants: N=107 Age: mean 49.2 (SD 9.8)y for milnacipran, mean 47.1 (SD 10.6)y for clomipramine; range 18‐70y
Interventions	Milnacipran 100‐200mg: N=52 Clomipramine 75‐150mg: N=55 Flexible dosing schedule.
Outcomes	Hamilton Depression Rating Scale‐17 item, MADRS, CGI‐S
Notes	Funding: by industry
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomised". Probably done.
Allocation concealment (selection bias)	Unclear risk	Insufficient information.
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "double‐blind"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing primary outcome.
Selective reporting (reporting bias)	High risk	Number of participants who dropped out the trial is missing.
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists.