Sechter 2000.

Methods	6 week randomised double blind study
Participants	Diagnosis: Outpatients with DSM‐IV major depressive disorder Male and Female. Threshold of baseline severity: MADRS>=20 Total number of all allocated participants: N=302 Age: mean 44.8 (SD 11.6)y for milnacipran, mean 42.8 (SD 11.2)y for paroxetine; range 18‐70y
Interventions	Milnacipran 100mg: N=149 Imipramine 20mg: N=153 Fixed dosing schedule.
Outcomes	Hamilton Depression Rating Scale‐17 item, MADRS, CGI‐I, CGI‐S
Notes	Funding: by industry
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "randomised"
Allocation concealment (selection bias)	Unclear risk	Unclear
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "double‐blind"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing primary outcome.
Selective reporting (reporting bias)	High risk	Missing standard deviations.
Other bias	Unclear risk	Insufficient information to assess whether an important risk of bias exists.