Table 2.
Top 40 most significant GO terms associated with RA.
| GOID | TERM | Annotated | Significant | Expected | P-value |
|---|---|---|---|---|---|
| GO:0006955 | Immune response | 690 | 111 | 17.79 | 4.69E-58 |
| GO:0002376 | Immune system process | 998 | 130 | 25.73 | 5.26E-58 |
| GO:0002682 | Regulation of immune system process | 385 | 73 | 9.93 | 5.48E-42 |
| GO:0048583 | Regulation of response to stimulus | 465 | 75 | 11.99 | 3.85E-38 |
| GO:0050776 | Regulation of immune response | 226 | 52 | 5.83 | 7.16E-34 |
| GO:0002684 | Positive regulation of immune system process | 238 | 52 | 6.14 | 1.06E-32 |
| GO:0050896 | Response to stimulus | 3502 | 194 | 90.30 | 6.22E-32 |
| GO:0006952 | Defense response | 615 | 73 | 15.86 | 2.68E-28 |
| GO:0050865 | Regulation of cell activation | 175 | 41 | 4.51 | 6.38E-27 |
| GO:0051239 | Regulation of multicellular organismal process | 937 | 87 | 24.16 | 2.87E-26 |
| GO:0002694 | Regulation of leukocyte activation | 166 | 39 | 4.28 | 1.21E-25 |
| GO:0006954 | Inflammatory response | 325 | 50 | 8.38 | 3.72E-24 |
| GO:0042221 | Response to chemical stimulus | 1281 | 99 | 33.03 | 5.39E-24 |
| GO:0048584 | Positive regulation of response to stimulus | 236 | 43 | 6.09 | 1.13E-23 |
| GO:0001817 | Regulation of cytokine production | 181 | 38 | 4.67 | 3.78E-23 |
| GO:0051249 | Regulation of lymphocyte activation | 148 | 35 | 3.82 | 4.24E-23 |
| GO:0031347 | Regulation of defense response | 143 | 34 | 3.69 | 1.62E-22 |
| GO:0050863 | Regulation of T cell activation | 117 | 31 | 3.02 | 5.35E-22 |
| GO:0050778 | Positive regulation of immune response | 145 | 33 | 3.74 | 3.13E-21 |
| GO:0006950 | Response to stress | 1685 | 110 | 43.45 | 5.19E-21 |
| GO:0048518 | Positive regulation of biological process | 2033 | 123 | 52.42 | 5.31E-21 |
| GO:0051704 | Multiorganism process | 681 | 66 | 17.56 | 1.20E-20 |
| GO:0002697 | Regulation of immune effector process | 101 | 28 | 2.60 | 1.97E-20 |
| GO:0080134 | Regulation of response to stress | 274 | 42 | 7.07 | 3.28E-20 |
| GO:0051240 | Positive regulation of multicellular organismal process | 244 | 39 | 6.29 | 2.06E-19 |
| GO:0010033 | Response to organic substance | 721 | 66 | 18.59 | 2.39E-19 |
| GO:0002237 | Response to molecule of bacterial origin | 86 | 25 | 2.22 | 8.96E-19 |
| GO:0009605 | Response to external stimulus | 914 | 74 | 23.57 | 1.00E-18 |
| GO:0009607 | Response to biotic stimulus | 384 | 47 | 9.90 | 1.38E-18 |
| GO:0050867 | Positive regulation of cell activation | 111 | 27 | 2.86 | 3.73E-18 |
| GO:0019882 | Antigen processing and presentation | 83 | 24 | 2.14 | 5.74E-18 |
| GO:0009611 | Response to wounding | 530 | 54 | 13.67 | 8.65E-18 |
| GO:0001775 | Cell activation | 287 | 40 | 7.40 | 8.77E-18 |
| GO:0002696 | Positive regulation of leukocyte activation | 106 | 26 | 2.73 | 1.40E-17 |
| GO:0002819 | Regulation of adaptive immune response | 56 | 20 | 1.44 | 6.63E-17 |
| GO:0050670 | Regulation of lymphocyte proliferation | 83 | 23 | 2.14 | 8.69E-17 |
| GO:0048519 | Negative regulation of biological process | 1812 | 106 | 46.72 | 1.02E-16 |
| GO:0070663 | Regulation of leukocyte proliferation | 84 | 23 | 2.17 | 1.15E-16 |
| GO:0032944 | Regulation of mononuclear cell proliferation | 84 | 23 | 2.17 | 1.15E-16 |
| GO:0051251 | Positive regulation of lymphocyte activation | 97 | 24 | 2.50 | 2.50E-16 |