Comparison 1.
Adjuvant chemotherapy versus observation
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Overall 5-yr survival | 3 | 1008 | Hazard ratio (Random, 95% CI) | 0.71 [0.53, 0.93] |
| 2 Overall 10-yr survival | 2 | 925 | Hazard Ratio (Random, 95% CI) | 0.74 [0.58, 0.95] |
| 3 Overall 5-yr survival (subgrouped by surgical staging) | 3 | Hazard ratio (Random, 95% CI) | Subtotals only | |
| 3.1 Optimal staging | 2 | 234 | Hazard ratio (Random, 95% CI) | 1.22 [0.63, 2.37] |
| 3.2 Sub-optimal staging | 2 | 772 | Hazard ratio (Random, 95% CI) | 0.63 [0.46, 0.85] |
| 4 Overall 10-yr survival (subgrouped by risk) | 1 | Hazard ratio (Random, 95% CI) | Subtotals only | |
| 4.1 Low/medium risk | 1 | Hazard ratio (Random, 95% CI) | 0.95 [0.54, 1.66] | |
| 4.2 High risk | 1 | Hazard ratio (Random, 95% CI) | 0.48 [0.32, 0.72] | |
| 5 Progression-free 5-yr survival | 4 | 1170 | Hazard ratio (Random, 95% CI) | 0.67 [0.53, 0.84] |
| 6 Progression-free 10-yr survival | 2 | 925 | Hazard Ratio (Random, 95% CI) | 0.67 [0.54, 0.84] |
| 7 Progression-free 5-yr survival (subgrouped by surgical staging) | 4 | Hazard ratio (Random, 95% CI) | Subtotals only | |
| 7.1 Optimal staging | 2 | 234 | Hazard ratio (Random, 95% CI) | 0.67 [0.36, 1.22] |
| 7.2 Sub-optimal staging | 3 | 934 | Hazard ratio (Random, 95% CI) | 0.64 [0.50, 0.82] |
| 8 Progression-free 10-yr survival (subgrouped by surgical staging) | 1 | Hazard Ratio (Random, 95% CI) | Subtotals only | |
| 8.1 Optimal staging | 1 | 151 | Hazard Ratio (Random, 95% CI) | 0.73 [0.38, 1.42] |
| 8.2 Sub-optimal staging | 1 | 295 | Hazard Ratio (Random, 95% CI) | 0.60 [0.41, 0.87] |
| 9 Progression-free 10-yr survival (subgrouped by risk) | 1 | Hazard ratio (Random, 95% CI) | Subtotals only | |
| 9.1 Low/medium | 1 | Hazard ratio (Random, 95% CI) | 0.96 [0.58, 1.59] | |
| 9.2 High | 1 | Hazard ratio (Random, 95% CI) | 0.52 [0.33, 0.82] | |
| 10 Disease-specific 5-yr survival | 1 | Hazard ratio (Random, 95% CI) | Subtotals only | |
| 11 Disease-specific 10-yr survival (subgrouped by surgical staging) | 1 | Hazard Ratio (Random, 95% CI) | Subtotals only | |
| 11.1 Optimal staging | 1 | 151 | Hazard Ratio (Random, 95% CI) | 1.58 [0.61, 4.09] |
| 11.2 Sub-optimal staging | 1 | 295 | Hazard Ratio (Random, 95% CI) | 0.58 [0.35, 0.96] |
| 12 Death from ovarian cancer (5 years) | 3 | 693 | Risk Ratio (M-H, Random, 95% CI) | 0.76 [0.52, 1.11] |
| 13 Death from ovarian cancer (10 years) | 1 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 13.1 Optimal staging | 1 | 151 | Risk Ratio (M-H, Random, 95% CI) | 1.55 [0.64, 3.79] |
| 13.2 Sub-optimal staging | 1 | 295 | Risk Ratio (M-H, Random, 95% CI) | 0.62 [0.40, 0.97] |