| Methods | Multicentre randomised controlled trial | |
| Participants | 448 FIGO Ia-Ib G2/3, FIGO Ic-IIa, FIGO I-IIa clear cell | |
| Interventions | Immediate platinum-based chemotherapy versus treatment on progression Cisplatin dose = 75 mg/m2 Carboplatin dose = 350 mg/m2 |
|
| Outcomes | DFS and OS Adverse events not reported Median follow-up: 5.5 years |
|
| Notes | Subgroup analysis examined impact of staging adequacy | |
| Risk of bias | ||
| Bias | Authors’ judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Based on minimisation |
| Allocation concealment (selection bias) | Low risk | Minimisation performed by central co-ordinating centres |
| Incomplete outcome data (attrition bias) All outcomes |
Low risk | T: 6/224 (2%) C: 3/224 (1%) |
| Blinding of outcome assessors (detection bias) | High risk | No blinding |
| Selective reporting (reporting bias) | Unclear risk | Intention-to-treat analysis; all pre-specified outcomes reported |