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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Cochrane Database Syst Rev. 2012 Mar 14;3:CD004706. doi: 10.1002/14651858.CD004706.pub4
Methods Multicentre randomised controlled trial
Participants 448 FIGO Ia-Ib G2/3, FIGO Ic-IIa, FIGO I-IIa clear cell
Interventions Immediate platinum-based chemotherapy versus treatment on progression
Cisplatin dose = 75 mg/m2
Carboplatin dose = 350 mg/m2
Outcomes DFS and OS
Adverse events not reported
Median follow-up: 5.5 years
Notes Subgroup analysis examined impact of staging adequacy
Risk of bias
Bias Authors’ judgement Support for judgement
Random sequence generation (selection bias) Low risk Based on minimisation
Allocation concealment (selection bias) Low risk Minimisation performed by central co-ordinating centres
Incomplete outcome data (attrition bias)
All outcomes
Low risk T: 6/224 (2%)
C: 3/224 (1%)
Blinding of outcome assessors (detection bias) High risk No blinding
Selective reporting (reporting bias) Unclear risk Intention-to-treat analysis; all pre-specified outcomes reported