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. 2014 Jul 25;155(10):4104–4112. doi: 10.1210/en.2014-1154

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Copyright © 2014 by the Endocrine Society

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Figure 4. — Effect of PTU or PBDE treatment on thyroid hormone action in heart on P21. A, myHC6 mRNA levels were significantly affected by PTU treatment (F_3,28 = 10.4; P < .0001, n = 5–10/group). Post hoc analysis revealed that myHC6 mRNA levels were significantly reduced in animals treated with 3 ppm PTU compared with controls. In contrast, PBDE treatment did not affect myHC6 mRNA levels (F_4,27 = 0.83; P = NS, n = 5–8/group). B, myHC7 mRNA levels were significantly affected by PTU treatment (F_3,26 = 4.34; P < .01, n = 5–10/group). Post hoc analysis revealed that myHC7 mRNA levels were significantly higher in animals treated with 3 ppm PTU compared with controls. In contrast, myHC7 mRNA levels were not affected by PBDE treatment (F_4,27 = 0.51; P = NS, n = 5–8/group). C, MDR1a mRNA levels in heart were significantly reduced by PTU treatment (F_3,27 = 3.8; P < .02, 5–10/group). Post hoc analysis showed that all MDR1a mRNA levels were reduced in all PTU-treated animals compared with controls. In contrast, PBDE treatment did not affect MDR1a mRNA levels in heart (F_4,25 = 0.8; P = NS, n = 5–8/group).