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. 2014 Jul 22;155(10):3732–3738. doi: 10.1210/en.2014-1223

Figure 3.

Figure 3.

Lorcaserin, d-fenfluramine, and sibutramine anorectic potency is maintained with aging. A, C, and E, Three-hour dark cycle food intake in male mice aged 3–5 months (t7 = 4.97, P = .0018) or 12–14 months (t7 = 5.21, P = .0013) after d-fenfluramine (dFEN, 3 mg/kg) or saline (A), in male mice aged 3–5 months (t7 = 5.30, P = .0053) or 12–14 months (t7 = 5.00, P = .0088) after sibutramine (SIB, 5 mg/kg) or saline (C), or in male mice aged 3–5 months (t4 = 3.38, P = .028) or 12–14 months (t7 = 3.40, P = .012) after lorcaserin (LORC, 8 mg/kg) or saline (E). B, D, and F, Three-hour dark cycle food intake in female mice aged 3–5 months (t7 = 3.6, P = .0038) or 12–14 months (t7 = 3.91, P = .0082) after dFEN (3 mg/kg) or saline (B), in female mice aged 3–5 months (t5 = 5.34, P = .0075) or 12–14 months (t5 = 5.11, P = .0093) SIB (5 mg/kg) or saline (D), or in female mice aged 3–5 months (t11 = 3.00, P = .012) or 12–14 months (t5 =3.28, P = .022) after LORC (8 mg/kg) or saline (F). Data are presented as mean ± SEM. *, P < .05; **, P < .01 analyzed with paired t test.