Figure 5.

Phenotype of mutant mice-breeding and serum hormones. A, Results of the breeding study in which the numbers of pups/litter were monitored from at least 3 litters/cage containing control parents, and parents with either a mutant male or female, or 2 mutant parents. Time to first litter was monitored for 7 mutant females, and 4 of these females had significantly delayed litters, causing a 36% increase in numbers of days with the male before the first litter. No pregnancy was noted until the last 2 weeks. B, Significant reduction in the number of pups/litter in litters from parents that included a mutant female. A star indicates significantly or males; controls vs mutant female, P = .01 or vs 2 Cre+ male parent, P = .02; Student's t test.