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. 2014 Jul 25;155(10):3956–3969. doi: 10.1210/en.2013-2095

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Copyright © 2014 by the Endocrine Society

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Figure 8. — Feeding studies in rats electroporated with control siRNA or SOCS3 siRNA or after ghrelin antagonist treatment. A, Food intake increased in the 12-h fasted rats electroporated with control siRNA, during the first 3 h of feeding. This increase was significantly reduced in the group of rats whose NG were electroporated with SOCS3 siRNA during the first 3 h of feeding. B, Ghrelin antagonist 400nM [D-Lys3]-GHRP-6 significantly reduced food intake during the 3 h of feeding compared with the feeding in rats after a 12-h fast. C, Food intake in nonfasted rats was less during the first 3 h of feeding compared with the rats fasted for 12 h. Electroporation of the rat NG with SOCS3 siRNA had no effect on food intake in the nonfasted rats. D, RT-PCR-verified SOCS3 gene knockdown 5 days after electroporation of the NG with control or SOCS3 siRNA. SOCS3 expression was inhibited by > 70% compared with control siRNA electroporation. The data are representative of 3–5 rats in each experimental group. *, P < .05, significantly different from the control fasting group.