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Feedback between phosphorus and FGF23/Fgf23 in mouse models. Because expression of human FGF23 transgene is controlled by doxycycline levels, feedback loops between phosphorus and FGF23 in these mice are disrupted. In contrast, Galnt3 knockout mice and mouse Fgf23 ADHR knock-in mice retain the feedback loops. KO, knockout; Tg, transgenic; KI, knock-in.
