Figure 4.

Integrative biology combining multiple experimental approaches with statistical inference and modeling approaches. Structural data on the Nup84 complex was derived from domain mapping, negative stain electron microscopy, and x-ray crystallography experiments and integrated with comparative data modeling and bioinformatics methods. The resulting structural models were then overlaid with data from functional mapping experiments. The process is refined by iteration and results in a set of possible structural configurations from which inferences can be made regarding the dynamics of this subcomplex within the much larger nuclear pore complex. Reproduced from Fernandez-Martinez et al. (2012).