Comparison 9. EBRT vs. No EBRT: Adverse effects.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Acute toxicity (all grades)	2	1328	Risk Ratio (M‐H, Random, 95% CI)	2.97 [1.49, 5.92]
2 Severe acute toxicity (G3/4)	2	1328	Risk Ratio (M‐H, Random, 95% CI)	4.68 [1.35, 16.16]
3 Late toxicity (all grades)	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4 Severe late toxicity (G3/4)	6	3501	Risk Ratio (M‐H, Random, 95% CI)	2.58 [1.61, 4.11]
4.1 EBRT vs. no additional treatment	2	1106	Risk Ratio (M‐H, Random, 95% CI)	6.74 [1.53, 29.74]
4.2 EBRT vs. no additional treatment (VBT balanced across groups)	2	1445	Risk Ratio (M‐H, Random, 95% CI)	2.19 [1.25, 3.85]
4.3 EBRT vs. VBT	2	950	Risk Ratio (M‐H, Random, 95% CI)	2.78 [1.01, 7.67]