TABLE 2.

Individual pharmacokinetic parameters of BUP in pregnant and postpartum baboons following a 1-mg/kg i.v. bolus dose of BUP

P values from repeated-measures ANOVA: CL, 0.060; C_max, 0.208; AUC_0–∞, 0.078.

	Midpregnancy			Late Pregnancy			Postpartum
	CL	Cmax	AUC0–∞	CL	Cmax	AUC0–∞	CL	Cmax	AUC0–∞
	l/h/kg	ng/ml	h·ng/ml	l/h/kg	ng/ml	h·ng/ml	l/h/kg	ng/ml	h·ng/ml
Study animal
1	3.5	375.4	318.2				3.0	383.0	364.3
2				3.4	333.9	308.1	2.8	420.3	356.9
3	3.6	311.3	275.4	3.5	440.0	292.6	2.4	369.4	399.6
4	3.8	195.7	269.4	4.0	243.5	263.0	2.3	250.9	446.4
5	3.5		288.2	3.0	304.0	344.8	2.9	379.8	341.4
Mean	3.6	294.1	287.8	3.48	330.4	302.1	2.68	360.7	381.7
S.D.	0.14	91.1	21.7	0.41	82.2	34.1	0.31	64.3	42.0