TABLE 3.

Individual pharmacokinetic parameters of OH-BUP in pregnant and postpartum baboons following a 1-mg/kg i.v. bolus dose of BUP

P values from repeated-measures ANOVA: C_max, 0.373; t_max, 0.751; AUC_0–∞, 0.102.

	Midpregnancy			Late Pregnancy			Postpartum
	Cmax	tmax	AUC0–∞	Cmax	tmax	AUC0–∞	Cmax	tmax	AUC0–∞
	ng/ml	h	h·ng/ml	ng/ml	h	h·ng/ml	ng/ml	h	h·ng/ml
Study animal
1	85.5	0.5	211.0				110.7	0.5	310.1
2				99.1	0.75	344.7	232.1	0.5	636.9
3	62.5	0.5	109.6	26.3	0.75	71.3	72.3	0.25	201.0
4	108.0	0.5	288.3	98.7	0.5	292.5	83.5	1	302.7
5	82.8	0.75	165.3	66.1	1	200.2	177.9	0.5	315.9
Mean	84.7	0.6	194	72.6	0.8	227	135	0.6	353
S.D.	18.6	0.1	76	34.5	0.2	120	68	0.3	165