TABLE 5.

Individual pharmacokinetic parameters of TB in pregnant and postpartum baboons following a 1-mg/kg i.v. bolus dose of BUP

	Midpregnancy			Late Pregnancy			Postpartum
	Cmax	tmax	AUC0–∞	Cmax	tmax	AUC0–∞	Cmax	tmax	AUC0–∞
	ng/ml	h	h·ng/ml	ng/ml	h	h·ng/ml	ng/ml	h	h·ng/ml
Study animal
2				1.52	2.00	9.83	1.65	1.00	6.57
3	1.74	0.75	5.90	1.35	1.00	5.48	1.75	1.00	6.47
5	2.22	0.75	7.67	3.24	0.75	11.51	1.84	0.50	6.02
Mean	1.98	0.75	6.8	2.04	1.25	8.9	1.75	0.83	6.4
S.D.	0.34	0.00	1.3	1.05	0.66	3.1	0.10	0.29	0.3