TABLE 1.

Biophysical properties of Na_v1.5 channels

Property	Nav1.5/WT Control		Nav1.5/WT Fluoxetine
	Mean ± S.E.M.	n	Mean ± S.E.M.	n
Steady-state activation
V1/2, mV	−43.49 ± 1.46	14	−41.52 ± 1.17	18
kv	−6.13 ± 0.32	14	7.28 ± 0.17a	18
Steady-state inactivation
V1/2, mV	−87.34 ± 0.94	19	−94.04 ± 1.64b	17
kv	6.37 ± 0.19	19	7.67 ± 0.29b	17
Recovery from inactivation
τ1	1.50 ± 0.1	10	1.63 ± 0.1	6
A1	76.3 ± 2.7	10	35.7 ± 2.1	6
τ 2	9.13 ± 1.0	10	14.90 ± 2.6	6
A2	23.7 ± 0.8	10	22.0 ± 2.1	6
τ 3	—	—	1598.23 ± 41.6	6
A3	—	—	42.3 ± 1.7	6

A, fraction of the τ components (%); k_v, slope factor for activation or inactivation; n, number of cells; τ, time constant; V_1/2, midpoint for activation or inactivation.

^aP < 0.01.

^bP < 0.001.