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. 2004 Jun;78(12):6287–6296. doi: 10.1128/JVI.78.12.6287-6296.2004

FIG. 7.

FIG. 7.

sCD4 preferentially inhibits infection by X4-tropic HIV-1. X4- and R5-tropic viral isolates (A) and V3 loop mutants (B) were produced in 293T cells. Virions were treated with the indicated concentrations of sCD4 and assayed for infection on P4/CCR5+ reporter cells as described in Materials and Methods. Values are expressed as a percentage of the infectivity of the corresponding untreated virus. Shown is a representative of up to three experiments. Filled symbols, X4-tropic HIV-1; open symbols, R5-tropic HIV-1.