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Schematic presentation of the neurochemical (RVLM) and BP responses elicited by activating central GPR18. Activation of intra-RVLM GPR18 inhibits cAMP leading to enhanced pERK1/2 and pAkt production, which causes p-nNOS (NO)–dependent elevation in ADN, and ultimately reductions in RVLM ROS and BP.
