Figure 2.

Least square (LS) means (± standard error) of the total neonatal abstinence syndrome (NAS) in methadone- and buprenorphine-exposed neonates from birth to 240 hours postnatal (PN). A ‘0’ was plotted for time-points where the LS mean was negative. All figures illustrate significant main effects of medication condition and of time (Ps < 0.05). The numerical range after the name of each individual sign indicates the minimum and maximum score for that sign. The y-axis is presented on a smaller scale for most signs to allow for more detailed inspection of the data