FIG. 2.

Development of neurological disease in wild-type, CCR2^−/−, and CCR5^−/− mice. Wild-type, CCR2^−/−, and CCR5^−/− mice were inoculated with Fr98-infected NSC by intraventricular inoculation within 24 h after birth. The mice were then monitored for the development of clinical signs of severe ataxia, seizures, or death. Data are presented as the percentage of mice with severe ataxia or death for 35 wild-type mice, 57 CCR5^−/− mice, and 46 CCR2^−/− mice. Statistical analysis was done by Kaplan-Meier survival curve analysis using Graphpad Prism. The P value for the two-tailed log rank (Mantel-Haenszel) test for trends between all three groups was 0.022. The P values for the two-tailed log rank test between individual groups were 0.022 for CCR2^−/− versus wild-type mice, 0.95 for CCR5^−/− versus wild-type mice, and 0.011 for CCR2^−/− versus CCR5^−/− mice.