FIG. 7.
Effect of anti-MCP-1, anti-MCP-3, or anti-MCP-5 on neurological disease development following Fr98 infection. IRW mice were infected with 104 FFU of Fr98 by intraperitoneal inoculation within 24 h after birth. At 11 days postinfection, the mice were treated with 130 ng of antibody in 1% NGS-PBS by intracranial inoculation. They were then monitored for signs of ataxia and seizures. Data are presented as the percentage of mice with severe ataxia or dead for 12 to 16 mice per group. Statistical analysis was done by Kaplan-Meier survival curve analysis using Graphpad Prism. The P value for the two-tailed log rank test for trend between all three groups was 0.015. The P values for the two-tailed log rank test between individual groups were 0.006 for control Ig versus anti-MCP-1-treated mice, 0.76 for control Ig versus anti-MCP-3-treated mice, and 0.35 for control Ig versus anti-MCP-5-treated mice.